Antibiotic 107891, its factors A1 and A2, pharmaceutically acceptable salts and compositions, and use thereof

US7307057B2 · kind B2 · utility

Assignee

• NAICONS S.c.a.r.l. · IT

Inventors

• Ameriga Lazzarini · Legnano, IT
• Luciano Gastaldo · Pogliano Milanese, IT
• Gianpaolo Candiani · Gorgonzola, IT
• Ismaela Ciciliato · Busto Arsizio, IT
• Daniele Losi · Rovellasca, IT
• Flavia Marinelli · Milano, IT
• Enrico Selva · Gropello Cairoli, IT
• Franco Parenti · Lainate, IT

Key dates

• Filing date: Jul 12, 2004
• Grant date: Dec 11, 2007
• Expiry date: Jul 12, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12R2001/01
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to an antibiotic substance of microbial origin, arbitrarily denominated antibiotic 107891 which is produced by fermentation of Microbispora sp. ATCC PTA-5024, the pharmaceutically acceptable salts and compositions thereof, and their use as an antibacterial agent having inhibitory activity versus susceptible microbes.Antibiotic 107891 and its Factors A1 and A2 show a good antibacterial activity against Gram-positive bacteria including methicillin resistant and vancomycin resistant strains, and is active also against some Gram-negative bacteria such as M. catharralis, Neisseria species and H. influenzae and Mycobacteria.