2′-Fluoronucleosides

US7307065B2 · kind B2 · utility

Assignees

• EMORY UNIVERSITY · US
• University of Georgia Research Foundation, Inc. · US

Inventors

• Raymond F. Schinazi · Decatur, US
• Dennis C. Liotta · Atlanta, US
• Chung K. Chu · Statham, US
• J. Jeffrey McAtee · Atlanta, US
• Junxing Shi · Duluth, US
• Yongseok Choi · Athens, US
• Kyeong Lee · Athens, US
• Joon H. Hong · Athens, US

Key dates

• Filing date: Mar 8, 2004
• Grant date: Dec 11, 2007
• Expiry date: Feb 4, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A class of 2′-fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formulae:wherein