Patent · US Expired

Method for screening for activators of soluble guanylate cyclase having oxidized heme iron

US7309579B2 · kind B2 · utility

5Cited by

5References

15Claims

0Family size

Assignee

Sanofi-Aventis Deutschland GMBH · DE

Inventors

Ursula Schindler · Bad Soden, DE
Hartmut Strobel · Liederbach, DE
Peter Schindler · Rodgau, DE
Alexander Muelsch · Heidelberg, DE

Key dates

Filing date	Jun 3, 2005
Grant date	Dec 18, 2007
Priority date	—
Expiry date	Jul 5, 2025

Classification

Technology area (CPC G)Physics
CPC primaryG01N2500/00
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention relates to methods for detecting a soluble guanylate cyclase whose heme iron is in the trivalent oxidation state, and to methods for finding chemical substances which stimulate the activity of a soluble guanylate cyclase when the heme iron of at least part of this soluble guanylate cyclase is oxidized to the trivalent state and also to diagnostic aids or kits for detecting a soluble guanylate cyclase with trivalent heme iron. Further, the invention relates methods for detecting a soluble guanylate cyclase lacking a heme group, and to methods for finding chemical substances which stimulate the activity of a soluble guanylate cyclase lacking a heme group.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.