Polymers for the delivery of bioactive agents and methods of their preparation
US7309757B2 · kind B2 · utility
2Cited by
8References
14Claims
0Family size
Assignee
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Key dates
| Filing date | Jun 20, 2003 |
| Grant date | Dec 18, 2007 |
| Priority date | — |
| Expiry date | Nov 15, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08G73/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided is a poly(amino ester) having a polymer backbone comprising at least one secondary amine linkage and at least one tertiary amine linkage in the polymer backbone. Poly(amino ester)s are prepared via the Michael addition of a bis(acrylate ester)monomer to a diamine monomer, wherein the diamine monomer has one primary amino group and one secondary amino group, and can be end-capped by reaction with a suitable reagent. The inventive poly(amino ester)s may be used as vectors for delivery of a bioactive agent, such as DNA, to a cell.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.