Conjugates comprising human IL-18 and substitution mutants thereof
US7311902B2 · kind B2 · utility
10Cited by
3References
34Claims
0Family size
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Key dates
| Filing date | Apr 14, 2004 |
| Grant date | Dec 25, 2007 |
| Priority date | — |
| Expiry date | Nov 21, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Human interleukin-18 (IL-18) polypeptides and substitution mutants thereof were conjugated to water-soluble polymers at specific sites on the human IL-18 protein. These conjugated human IL-18 and substitution mutants thereof retain biological activity. These conjugated cytokines demonstrate enhanced and unexpected biological properties when compared to the corresponding unconjugated cytokines.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.