Process for the production of (−)-epigallocatechin gallate

US7312199B2 · kind B2 · utility

Assignee

• DSM IP ASSETS B.V. · NL

Inventors

• David Burdick · Guilderland, US
• Heinz Egger · Muttenz, CH
• Andrew George Gum · Rixheim, FR
• Ingo Koschinski · Berlin, DE
• Elena Muelchi · Münchenstein, CH
• Isabelle Prevot-Halter · La Valette-du-Var, FR

Key dates

• Filing date: Nov 9, 2005
• Grant date: Dec 25, 2007
• Expiry date: Nov 9, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H17/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process is provided for making (−)-epigallocatechin gallate (EGCG) by subjecting a green tea extract to chromatography on a macroporous polar resin, eluting EGCG from the resin with a polar elution solvent, optionally concentrating the eluate, optionally regenerating the resin by desorbing the remaining catechins, and optionally concentrating the desorbed catechins.