Pyrimidine derivatives

US7312224B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Hans-Micahel Eggenweiler · Darmstadt, DE
• Manfred Baumgarth
• Pierre Schelling · Mühltal, DE
• Norbert Beier · Reinheim, DE
• Maria Christadler · Darmstadt, DE

Key dates

• Filing date: Sep 4, 2002
• Grant date: Dec 25, 2007
• Expiry date: Nov 16, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pyrimidine derivatives of the formula (I) and physiologically acceptable salts thereof, in which R1, R2, R3, R4, W, X, Y and Z are as defined in claim 1, exhibit phosphodiesterase V inhibition and can be employed for the treatment of diseases of the cardiovascular system and for the treatment and/or therapy of potency disorders