Fluorescent labeled nucleotide derivatives
US7312326B2 · kind B2 · utility
0Cited by
3References
23Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 9, 2004 |
| Grant date | Dec 25, 2007 |
| Priority date | — |
| Expiry date | Apr 23, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC09B23/0066
- WIPO fieldBasic materials chemistry
- WIPO sectorChemistry
Abstract
Fluorescent labeled reporter compounds having a modified cyanine dye that is coupled to a nucleotide derivative through a linker are disclosed. The compounds are useful for nucleic acid sequence analysis. The fluorescent labeled reporter compounds are ring-locked cyanine dyes that are coupled to a nucleotide derivative, such as a modified DNA base, through a linker. These fluorescent labeled reporter compounds can be used as DNA chain-terminators in DNA synthesis to generate DNA fragments that are fluorescently-labeled at the 3′-terminal end of the DNA fragment.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.