Patent · US Expired

Process for the preparation of (3-cyano-1h-indol-7-yl) (4-(4-fluorophenethyl) piperazin-1-yl)-methanone and salts thereof

US7312342B2 · kind B2 · utility

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0References

26Claims

0Family size

Assignee

Merck Patent GmbH · DE

Inventors

Helene Crassier · Darmstadt, DE
Uwe Eckert · Darmstadt, DE
Henning Boettcher · Darmstadt, DE
Andreas Bathe · Darmstadt, DE
Steffen Emmert · Weiterstadt, DE

Key dates

Filing date	Dec 21, 2001
Grant date	Dec 25, 2007
Priority date	—
Expiry date	Dec 27, 2023

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D209/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to a process for the preparation of (3-cyano-1H-indol-7-yl)[4-(4-fluorophenethyl)piperazin-1-yl]-methanone and salts thereof, characterised in that an indole ester of the formula II in which R is as defined in Claim 1, is converter into 3-cyano-1H-indole-7-carboxylic acid via steps (1) to (4) according to Claim 1, and this is reacted with 1-[2-(4-fluorophenyl)ethyl]piperazine of salts thereof to give the product.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.