Recombinant sendai virus vector for introducing exogenous genes to airway epithelia
US7314614B1 · kind B1 · utility
4Cited by
7References
17Claims
0Family size
Assignee
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Key dates
| Filing date | Nov 2, 2000 |
| Grant date | Jan 1, 2008 |
| Priority date | — |
| Expiry date | Nov 2, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2760/18871
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided are a recombinant Sendai virus vector for introducing exogenous genes to airway epithelia and a method for introducing exogenous genes using the vector. The recombinant Sendai virus vector enables efficient gene transfer to native mucus-layered airway epithelial cells by briefly contacting the vector with the cells. Furthermore, the vector can introduce genes to not only apical surfaces but also submucosal glands where CFTR primarily expresses. The vector can thus be used for gene therapy of CF, a CFTR-deficient disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.