Methods and materials for characterizing and modulating interaction between heregulin and HER3

US7314916B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Elizabeth Singer · Duarte, US
• Ralf Landgraf · San Fernando, US
• Dennis Slamon · Los Angeles, US
• David S. Eisenberg · Los Angeles, US

Key dates

• Filing date: Apr 19, 2006
• Grant date: Jan 1, 2008
• Expiry date: Apr 19, 2026

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/9121
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The disclosure provided herein identifies and characterizes the domain in HER3 receptor that interacts with heregulin ligand. Typical embodiments of the invention disclosed herein include HER3 variant polypeptides having amino acid sequences which differ from the native HER3 polypeptide sequence and which have altered affinities for heregulin. Also disclosed herein are methods and materials for identifying compounds that bind to the heregulin binding domain in HER3 as well as methods and materials for modulating the interaction between HER3 and heregulin.