Carotenoid ester analogs or derivatives for the inhibition and amelioration of ischemic reperfusion injury

US7317008B2 · kind B2 · utility

Assignee

• Cardax Pharmaceuticals, Inc. · US

Inventors

• Samuel Lockwood · Lake Linden, US
• Sean O'Malley · Honolulu, US
• David G. Watumull · Honolulu, US
• Laura M. Hix · San Francisco, US
• Henry Jackson · Honolulu, US
• Geoff Nadolski · Kaaawa, US

Key dates

• Filing date: Mar 4, 2004
• Grant date: Jan 8, 2008
• Expiry date: Apr 29, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H13/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method of treating ischemic reperfusion injury in a subject. The method may include administering to the subject an effective amount of a pharmaceutically acceptable formulation. The pharmaceutically acceptable formulation may include a synthetic analog or derivative of a carotenoid. The subject may be administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative, or co-antioxidant formulation. The carotenoid analog may include a conjugated polyene with between 7 to 14 double bonds. The conjugated polyene may include a cyclic ring including at least one substituent. In some embodiments, a cyclic ring of a carotenoid analog or derivative may include at least one substituent. The substituent may be coupled to the cyclic ring with an ester functionality.