Chemical synthesis of reagents for peptide coupling
US7317129B2 · kind B2 · utility
7Cited by
4References
28Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 19, 2005 |
| Grant date | Jan 8, 2008 |
| Priority date | — |
| Expiry date | Sep 19, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/06026
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides improved methods for synthesis of phosphinothiol reagents, as well as novel protected reagents, for use in formation of amide bonds, and particularly, for peptide ligation. The invention provides phosphine-borane complexes useful as reagents in the formation of amide bonds, particularly for the formation of an amide bond between any two of an amino acid, a peptide, or a protein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.