C. elegans p21-activated kinase (PAK) gene and associated loss-of-function phenotypes that facilitate screening for small molecule modulators of PAK activity in the nematode, caenorhabditis elegans

US7319024B1 · kind B1 · utility

Assignee

• Sanofi-Aventis Deutschland GMBH · DE

Inventors

• Kaj Grandien · Kelkheim, DE
• Jonathan Rothblatt · Bound Brook Junction, US
• Paola CONCARI · Munich, DE
• Isabelle Quelo · Schwalbach, DE
• Bert Klebl · Dortmund, DE

Key dates

• Filing date: Jan 28, 2005
• Grant date: Jan 15, 2008
• Expiry date: Sep 14, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/14
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention refers to a novel C. elegans p21-activated kinase gene, the pak-3 gene, and associated loss-of-function phenotypes. These phenotypes can be used to elucidate PAK signaling pathways in C. elegans and to screen compounds that modulate PAK signaling.