Antidiabetic 2-substituted-5′-O-(1-Boranotriphosphate) adenosine derivatives

US7319093B2 · kind B2 · utility

Assignees

• Bar-Ilan University · IL
• Université Montpellier · FR

Inventors

• Bilha Fischer · Shoham, IL
• Victoria Kleiman-Nahum · Jerusalem, IL
• Pierre Petit · Verrières-le-Buisson, FR

Key dates

• Filing date: Oct 23, 2002
• Grant date: Jan 15, 2008
• Expiry date: Feb 12, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

2-Substituted-5′-O-(1-boranotriphosphate)adenosine derivatives having at position 2 a radical R1 selected from the group consisting of H; halogen; O-hydrocarbyl; S-hydrocarbyl; NR3R4; and hydrocarbyl optionally substituted by halogen, CN, SCN, NO2, OR3, SR3 or NR3R4; wherein R3 and R4 are each independently H or hydrocarbyl or R3 and R4 together with the nitrogen atom to which they are attached form a saturated or unsaturated heterocyclic ring optionally containing 1-2 further heteroatoms selected from oxygen, nitrogen and sulfur, and pharmaceutically acceptable salts or diastereoisomers thereof or a mixture of diastereoisomers, are useful for treatment of type 2 diabetes.