Thyroid hormone receptor antagonists for cardiac and metabolic disorders II

US7319096B2 · kind B2 · utility

Assignee

• Karo Bio AB · SE

Inventors

• Johan Malm · Älta, SE
• Peter Brandt · Uppsala, SE
• Karin Edvinsson · Stockholm, SE
• Thomas Ericsson
• Sandra Gordon · Mariefred, SE

Key dates

• Filing date: Apr 15, 2002
• Grant date: Jan 15, 2008
• Expiry date: Dec 5, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D277/24
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to novel compounds which are thyroid receptor ligands, preferably antagonists, and to methods for using such compounds in the treatment of cardiac and metabolic disorders, such as cardiac arrhythmias, thyrotoxicosis, subclinical hyperthyrodism and liver diseases.