Patent · US Expired

Methylenetetrahydrofolate reductase inhibitors and use thereof

US7319145B2 · kind B2 · utility

0Cited by
8References
35Claims
0Family size

Assignee

Inventors

Key dates

Filing dateDec 3, 2001
Grant dateJan 15, 2008
Priority date—
Expiry dateDec 3, 2021

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12Y105/0102
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

The present invention provides methylenetetrahydrofolate reductase (MTHFR) inhibitors for use in selective inhibition of cancer cell growth in a mammal. These inhibitors can be a small molecule, an antisense oligonucleotide, a ribozyme, a triple helix forming oligonucleotide, an anti-MTHFR antibody or fragment thereof, an MTHFR mutant or a fragment of MTHFR. The present invention further provides nucleic acids encoding an inhibitor of MTHFR, and vectors comprising these nucleic acids. Also encompassed by the present invention are methods of using the MTHFR inhibitors for selective inhibition of cancer cell growth, and pharmaceutical compositions comprising the MTHFR inhibitors.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.