Therapeutic use of growth factor, and delivery device, especially for the treatment of intimal hyperplasia
US7320679B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 19, 2003 |
| Grant date | Jan 22, 2008 |
| Priority date | — |
| Expiry date | Jul 3, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61F2250/0067
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention concerns vascular endothelial growth factor (VEGF) which has utility in the treatment of intimal hyperplasia, hypertension and atherosclerosis, and of conditions susceptible to treatment with agents that produce nitric oxide or prostacyclin. Instead of VEGF, an equivalent agent such as an agonist of VEGF receptors may be given, as may nucleic acid encoding such an agonist. The agent may successfully be administered via the adventitial surface of a blood vessel, e.g., using a device which defines a reservoir between the body wall and the vessel's adventitial surface, the reservoir being at least part-filled by a pharmaceutical formulation containing the agent to be delivered.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.