Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents

US7320993B1 · kind B1 · utility

Assignee

• Astellas Deutschland GmbH · DE

Inventors

• Elfi Biedermann · Vaterstetten, DE
• Max Hasmann · Schwanau, DE
• Roland Loser · Feldafing, DE
• Benno Rattel · Munich, DE
• Friedemann Reiter · Putzbrunn, DE
• Barbara Schein · Neufahrn, DE
• Klaus Seibel · Gräfelfing, DE
• Klaus Vogt · Munich, DE
• Katja Wosikowski · Poing, DE
• Isabel Schemainda · Munich, DE

Key dates

• Filing date: Jun 16, 2000
• Grant date: Jan 22, 2008
• Expiry date: Nov 24, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or several-fold unsaturated hydrocarbon residue in the carboxylic acid group, methods for the synthesis of these compounds, medicaments containing these and their production as well as their therapeutic use, especially as cytostatic agents and immunosuppressive agents, for example in the treatment or prevention of various types of tumors and control of immune reactions such as autoimmune diseases.