Benzimidazoles and benzothiazoles as inhibitors of map kinase

US7320995B2 · kind B2 · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• Rosanne Bonjouklian · Indianapolis, US
• Jose Eugenio De Diego Gomez · Madrid, ES
• Alfonso De Dios · Madrid, ES
• Chafiq Hamdouchi · Carmel, US
• Tiecho Li · Fishers, US
• Beatriz Lopez De Uralde Garmendia · Madrid, ES
• Michal Vieth · Carmel, US
• Jeremy Schulenberg York · Indianapolis, US
• Robert Dally · Indianapolis, US
• Miriam Filadelfa DEL PRADO CATALINA · Madrid, ES
• Carlos Jaramillo Aguado · Alcobendas, ES
• Luisa Martin-Cabrejas · Madrid, ES
• Carlos Montero Salgado · Madrid, ES
• Sheila Pleite Selgas · Madrid, ES
• Concepcion Sanchez-Martinez · Indianapolis, US
• Timothy Alan Shepherd · Indianapolis, US
• James H. Wikel · Greenwood, US

Key dates

• Filing date: Jul 31, 2003
• Grant date: Jan 22, 2008
• Expiry date: Mar 30, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides kinase inhibitors of Formula I: wherein W represents inter alia imidazol, oxazol, pyrazol, thiazol as triazol, which are substituted by phenyl or thienyl. The disclosed compounds inhibit p-38 kinase and are useful in the treatment of metastasis or rheumatoid arthritis