Pharmaceutical compositions including carotenoid ester analogs or derivatives for the inhibition and amelioration of disease

US7320997B2 · kind B2 · utility

Assignee

• Cardax Pharmaceuticals, Inc. · US

Inventors

• Samuel Lockwood · Lake Linden, US
• Sean O'Malley · Honolulu, US
• David G. Watumull · Honolulu, US
• Laura M. Hix · San Francisco, US
• Henry Jackson · Honolulu, US
• Geoff Nadolski · Kaaawa, US

Key dates

• Filing date: Mar 4, 2004
• Grant date: Jan 22, 2008
• Expiry date: Aug 10, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H13/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A method for inhibiting and/or ameliorating the occurrence of diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals in a subject whereby a subject is administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative, or co-antioxidant formulation. The analog or derivative is administered such that the subject's risk of experiencing diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals may be thereby reduced. In some embodiments, the invention may include a pharmaceutical composition including a carotenoid analog or derivative. The carotenoid analog may include a conjugated polyene with between 7 to 14 double bonds. The conjugated polyene may include a cyclic ring including at least one substituent. The substituent may be coupled to the cyclic ring with an ester functionality. The pharmaceutical composition may be adapted to be administered to a human subject.