Method for the catalytic production of hydrocodone and hydromorphone
US7321038B2 · kind B2 · utility
6Cited by
16References
32Claims
0Family size
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Key dates
| Filing date | Oct 25, 2004 |
| Grant date | Jan 22, 2008 |
| Priority date | — |
| Expiry date | May 17, 2025 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2531/827
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
A method for the catalytic conversion of codeine, morphine or analogs thereof into hydrocodone, hydromorphone or analogs thereof utilizing a transition metal catalyst of the formula [M(PR3R4R5)nXm]p; wherein R1 is H, alkyl, aryl or acyl; M is a Group VIII transition metal; R3, R4 and R5 are selected from the group consisting of alkyl, aryl, alkoxyl, phenoxyl and combinations thereof; X is a halide or an anion; n is 1, 2, 3 or 4; m is 1 or 2; and p is at least 1.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.