1,6 Naphthyridines useful as inhibitors of SYK kinase

US7321041B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim Pharmaceuticals, Inc. · US

Inventors

• Charles Cywin · Bethel, US
• Scott Jakes · Southbury, US
• Joachim Heider · Warthausen, DE
• Mark Bobko · Exton, US
• Renee L. Des Jarlais · Conshohocken, US
• Mark R. Player · Phoenixville, US
• James Rinker · Reading, US
• Michael Winters · Morgantown, US
• Bao-Ping Zhao · Plainsboro, US

Key dates

• Filing date: Apr 15, 2003
• Grant date: Jan 22, 2008
• Expiry date: Apr 1, 2025

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of formula (I):wherein R3, R5, R7 and R8 are defined herein, which are useful as inhibitors SYK kinase and are thus useful for treating diseases resulting from inappropriate mast cell activation, which include allergic and inflammatory diseases. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.