Processes for the preparation of 2-aminomethylpyridines and the 2-cyanopyridines used in their preparation
US7321043B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 8, 2005 |
| Grant date | Jan 22, 2008 |
| Priority date | — |
| Expiry date | Nov 30, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D213/61
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed herein is a process for the preparation of a compound of the formula (II):or a salt thereof, wherein X is halogen; each Y, which may be the same or different, is halogen, haloalkyl, alkoxycarbonyl or alkylsulphonyl, and n is 0 to 3;which process comprises treating a compound of the formula (III):with a cyanide source and a catalyst selected from the group consisting of a tetraalkyl ammonium salt and a tetraalkyl phosphonium salt in an aqueous solvent or without solvent, wherein:X is halogen; each Y, which may be the same or different, is halogen, haloalkyl, alkoxycarbonyl or alkylsulphonyl: and n is 0 to 3; and wherein the cyanide source is hydrogen cyanide, an alkali metal cyanide, an alkaline earth metal cyanide or an optionally substituted ammonium cyanide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.