Genes encoding novel proteolytic enzymes

US7323327B2 · kind B2 · utility

Assignee

• DSM IP ASSETS B.V. · NL

Inventors

• Luppo Edens · Rotterdam, NL
• Albertus Van Dijk · Vlaardingen, NL
• Philipp Krubasik · Martinsried, DE
• Kaj Albermann · Martinsried, DE
• Alexander Stock · Martinsried, DE
• Erik Kimpel · Munich, DE
• Sabine Klugbauer · Munich, DE
• Christian Wagner · Martinsried, DE
• Andreas Fritz · Martinsried, DE
• Wilk Von Gustedt · Planegg, DE
• Oliver Heinrich · Martinsried, DE
• Dieter Maier · Martinsried, DE
• Fabio Spreafico · Martinsried, DE
• Ulrike Folkers · Birkenfeld, DE
• Sylvia Hopper · Munich, DE
• Wolfram Kemmner · Munich, DE
• Pamela Tan · Kulmbach, DE
• Josephine Stiebler · Munich, DE
• Richard Albang · Martinsried, DE

Key dates

• Filing date: Feb 22, 2002
• Grant date: Jan 29, 2008
• Expiry date: Apr 1, 2022

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/38
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The invention relates to newly identified gene sequences that encode novel proteases obtainable from Aspergillus niger. The invention features the full length gene sequence of the novel genes, their cDNA sequences as well as the full-length functional protein and fragments thereof. The invention also relates to methods of using these enzymes in industrial processes and methods of diagnosing fungal infections. Also included in the invention are cells transformed with DNA according to the invention and cells wherein a protease according to the invention is genetically modified to enhance or reduce its activity and/or level of expression.