Myriceric acid derivatives for the treatment of cancer, cardiovascular and inflammatory diseases
US7323476B2 · kind B2 · utility
2Cited by
8References
2Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 1, 2007 |
| Grant date | Jan 29, 2008 |
| Priority date | — |
| Expiry date | Mar 1, 2027 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/216
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to the use of certain novel myriceric acid derivatives of the formula:which are inhibitors of nuclear factor kappa B (NF-κB) and inhibit the activity of the endothelin receptor for use in the treatment of cardiovascular and inflammatory diseases and for cancers susceptible to an NF-κB inhibitor and an endothelin receptor inhibitor. The present invention also relates to compounds and methods useful to inhibit cell proliferation and for the induction of apoptosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.