Processes and compounds for the preparation of substituted naphthylindole derivatives
US7323483B2 · kind B2 · utility
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3References
19Claims
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Assignee
Inventors
Key dates
| Filing date | Jan 25, 2006 |
| Grant date | Jan 29, 2008 |
| Priority date | — |
| Expiry date | Jan 25, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C49/84
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides processes for the preparation of substituted naphthylindole derivatives that can be used as inhibitors of plasminogen activator inhibitor-1(PAI-1). In certain embodiments of the invention, the processes involve reactions that include one or more of an Oppenauer oxidation, a Fischer indole synthesis, a methyl ether cleavage, or coupling a substituted methyltetrazole with a substituted naphthol.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.