Proline ester and preparation containing the same for percutaneous administration
US7323489B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 8, 2003 |
| Grant date | Jan 29, 2008 |
| Priority date | — |
| Expiry date | May 22, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A proline ester represented by the following formula (I):wherein R1 represents a hydroxy-lower alkyl group, a lower alkoxy-lower alkyl group, or a lower alkoxy-lower alkoxy-lower alkyl group or a pharmaceutically acceptable salt thereof.The proline ester (I) of the present invention and a pharmaceutically acceptable salt thereof are useful as a prodrug of enalaprilat, which is a medicine useful for preventing or treating circulatory diseases such as hypertension, cardiac diseases (e.g., cardiac hypertrophy, cardiac failure, and myocardial infarct), nephritis, and apoplexy. Thus, a drug containing the ester or a salt thereof is preferably formulated to a percutaneous preparation, particularly a patch, from the viewpoint of medicinal activity and use.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.