Hydride reduction of α,β-unsaturated carbonyl compounds using chiral organic catalysts
US7323604B2 · kind B2 · utility
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13Claims
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Key dates
| Filing date | Nov 21, 2005 |
| Grant date | Jan 29, 2008 |
| Priority date | — |
| Expiry date | Feb 20, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/07
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Nonmetallic, chiral organic catalysts are used to catalyze the 1,4-hydride reduction of an α,β-unsaturated carbonyl compound. The α,β-unsaturated carbonyl compound may be an aldehyde or cyclic ketone, and the hydride donor may be a dihydropyridine. The reaction is enantioselective, and proceeds with a variety of hydride donors, catalysts, and substrates. The invention also provides compositions effective in carrying out the 1,4-hydride addition of α,β-unsaturated carbonyl compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.