Device and method for monitoring leukocyte migration
US7326563B2 · kind B2 · utility
6Cited by
96References
45Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 12, 2002 |
| Grant date | Feb 5, 2008 |
| Priority date | — |
| Expiry date | Aug 24, 2024 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A device for monitoring leukocyte migration is provided. The device generally includes a plurality of chambers, each chamber including a channel in which leukocyte migration mediators or endothelial cells are disposed therein. The device is fabricated in the footprint of a standard microtiter plate. The invention also provides a method of using the device to monitor leukocyte migration in the presence of physiological shear flow and therefore simulate physiological conditions of a blood vessel in vivo. The invention further provides a method of using the device to high-throughput screen a plurality of test agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.