Process and intermediates for the preparation of (1R,2S,5S)-3-azabicyclo[3,1,0]hexane-2-carboxamide, N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[1,1-dimethylethyl]amino]carbonylamino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl

US7326795B2 · kind B2 · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Anantha Sudhakar · East Brunswick Township, US
• Vilas Dahanukar · Edison, US
• Ilia Zavialov · Plainsboro, US
• Cecilia Orr · Clark, US
• Hoa N. Nguyen
• Juergen Weber · Plainsboro, US
• Ingyu Jeon · Somerville, US
• Minzhang Chen · Acton, US
• Michael D. Green · Melbourne, AU
• George S. K. Wong · Summit, US
• Jeonghan Park · Flanders, US
• Tetsuo Iwama · Tokyo, JP

Key dates

• Filing date: Jun 15, 2004
• Grant date: Feb 5, 2008
• Expiry date: Jun 26, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

In one embodiment, the present application relates to a process of making a compound of formula I:and to certain intermediate compounds that are made within the process of making the compound of formula I.