Methods for increasing protein polyethylene glycol (PEG) conjugation
US7329516B2 · kind B2 · utility
7Cited by
2References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 11, 2005 |
| Grant date | Feb 12, 2008 |
| Priority date | — |
| Expiry date | Mar 11, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N9/88
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to highly conjugated proteins and methods for making such proteins. In particular, the present invention relates to methods for linking additional sites to a protein for conjugation with activated polyethylene glycol (PEG) linkers, without denaturing the protein. The invention also relates to highly conjugated proteins with decreased immunogenicity and increased circulating half-life.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.