Red blood cells loaded with S-nitrosothiol and uses therefor
US7329543B2 · kind B2 · utility
2Cited by
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8Claims
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Key dates
| Filing date | Jul 12, 2005 |
| Grant date | Feb 12, 2008 |
| Priority date | — |
| Expiry date | Feb 16, 2026 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/721
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Red blood cells can be loaded with low molecular weight nitrosylating agents, such as S-nitrosothiols, to act as a delivery system for NO+ groups to tissues. Loaded red blood cells can be used in methods of therapy for conditions which are characterized by abnormal O2 metabolism of tissues, oxygen-related toxicity, abnormal vascular tone, abnormal red blood cell adhesion, or abnormal O2 delivery by red blood cells. Such treatment of red blood cells can be extended to in vivo therapies, with the object to achieve an increase in the ratio of red blood cell S-nitrosothiol to hemoglobin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.