Method of treatment of hemorrhagic disease using a factor VIIa/tissue factor inhibitor
US7329640B2 · kind B2 · utility
14Cited by
24References
15Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Sep 12, 2006 |
| Grant date | Feb 12, 2008 |
| Priority date | — |
| Expiry date | Sep 12, 2026 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides methods of treating hemorrhagic fevers where selective inhibitors of fVIIa/TF are used as a treatment for hemorrhagic fevers and have therapeutic effects which include ameliorating and/or preventing coagulopathy and inflammatory responses. These inhibitors include certain proteins which are part of a family termed Nematode-Extracted Anticoagulant Proteins (“NAPs”). Other inhibitors include Tissue Factor Pathway Inhibitor (“TFPI”) and TFPI analogs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.