Substituted azabicyclic compounds
US7329675B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 1, 2004 |
| Grant date | Feb 12, 2008 |
| Priority date | — |
| Expiry date | Feb 5, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention is directed to physiologically active compounds of formula (I)whereinrepresents a bicyclic ring system, of about 10 to about 13 ring members, in which the ringis an azaheterocycle, and the ringrepresents an azaheteroaryl ring, or an optionally halo substituted benzene ring; and N-oxides thereof, and pharmaceutically acceptable salts of the compounds of formula (I) and N-oxides thereof,Such compounds inhibit the production or physiological effects of TNF and inhibit cyclic AMP phosphodiesterase. The invention is also directed to pharmnaceutical compositions comprising compoundS of formula (I), their phatmaceUtical use and methods for their preparation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.