Methods and compositions for controlled polypeptide synthesis
US7329727B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Nov 14, 2003 |
| Grant date | Feb 12, 2008 |
| Priority date | — |
| Expiry date | Jul 6, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08G69/10
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Methods and compositions for the generation of polypeptides having varied material properties are disclosed herein. Methods include means for initiating the polymerization of aminoacid-N-carboxyanhydride (NCA) monomer by combining the monomer with an amido-containing metallacycle, for making self assembling amphiphilic block copolypeptides and related protocols for adding oligo(ethyleneglycol) functionalized aminoacid-N-carboxyanhydrides (NCAs) to polyaminoacid chains. Additional methods include means of adding an end group to the carboxy terminus of a polyaminoacid chain by reacting an alloc-protected amino acid amide with a transition metal-donor ligand complex to forming an amido-amidate metallacycle for use in further polymerization reactions. Novel compositions for use in peptide synthesis and design including five and six membered amido-containing metallacycles and block copolypeptides are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.