Patent · US Expired

Composition for the elimination of autoreactive B-cells

US7332168B2 · kind B2 · utility

3Cited by

7References

2Claims

0Family size

Assignee

Micromet AG · DE

Inventors

Marcel Zocher · Germering, DE
Patrick Baeuerle · Gauting, DE
Torsten Dreier · Breda, NL

Key dates

Filing date	Aug 22, 2001
Grant date	Feb 19, 2008
Priority date	—
Expiry date	Dec 18, 2022

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02A50/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to a composition for the selective elimination of autoreactive B-cells comprising at least one (poly)peptide construct consisting of at least two domains wherein one of said domains comprises an autoreactive antigen or (a) fragments(s) thereof specifically recognized by the Ig receptors of said autoreactive B-cells and wherein one of said domains comprises an effector molecule capable of interacting with and/or of activating NK-cells, T-cells, macrophages, monocytes and/or granulocytes and/or capable of activating the complement system.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.