Mutant forms of cholera holotoxin as an adjuvant
US7332174B2 · kind B2 · utility
41Cited by
9References
21Claims
0Family size
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Key dates
| Filing date | Jun 5, 2002 |
| Grant date | Feb 19, 2008 |
| Priority date | — |
| Expiry date | Oct 25, 2023 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/55544
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Mutant cholera holotoxins having single or double amino acid substitutions or insertions have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in antigenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.