Methods to increase or decrease bone density
US7332276B2 · kind B2 · utility
9Cited by
0References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 28, 2003 |
| Grant date | Feb 19, 2008 |
| Priority date | — |
| Expiry date | Feb 9, 2024 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/51
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The SOST gene gives rise to sclerostin, a protein that leads to apoptosis of bone progenitor cells. The invention provides antagonists to the sclerostin protein, and methods for identifying new sclerostin antagonists. The invention also provides molecules that can depress expression of the SOST gene, as well as methods for identifying such molecules. Such molecules and antagonists are useful for increasing bone mineralization in mammals, for example, in the treatment of osteoporosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.