Hematopoietic stem cells treated by in vitro fucosylation and methods of use
US7332334B2 · kind B2 · utility
8Cited by
7References
61Claims
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Key dates
| Filing date | Jan 30, 2004 |
| Grant date | Feb 19, 2008 |
| Priority date | — |
| Expiry date | Apr 11, 2025 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2035/124
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of in vitro fucosylation of selectin ligands on cord blood-derived hematopoietic stem cells for bone marrow transplantation is disclosed. In this method, an effective amount of an α1,3-fucosyltransferase, e.g., α1,3-fucosyltransferase VI, is used in vitro to treat cord blood-derived hematopoietic stem cells to convert non-functional PSGL-1 or other ligands on the cell surface into functional forms that bind selectins, especially P-selectin or E-selectin. The treated cells have enhanced effectiveness in reconstituting bone marrow in patients in need of such therapy.
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