Treatment of chronic chalazion and hordeolum with botulinum toxin
US7335367B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Mar 8, 2004 |
| Grant date | Feb 26, 2008 |
| Priority date | — |
| Expiry date | Mar 8, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Chalazia and hordeola are the most common lesions occurring in the human eyelid, and often recurrences are managed by surgical intervention to remove fatty inclusions within the lid with associated inflammatory reaction. The present invention provides non-surgical methods of treating chalazia, hordeola and cutaneous infections comprising the administration of compositions comprising botulinum toxin. The present invention provides methods that effectively block meibum secretion from the meibomian glands, reduce sebaceous bacterial culture media on skin, and sebaceous secretion from the glands of Zeis. Decreased production of meibum and associated fatty substances resulting from the methods of the present invention, decrease gland blockage and tissue inspissations, resulting in reduced recurrence of chalazia, hordeola and related inflammatory reactions and lesions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.