Generation of nitric oxide in vivo from nitrite, nitrate or nitrosothiols endogenous in blood
US7335383B2 · kind B2 · utility
22Cited by
17References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 5, 2004 |
| Grant date | Feb 26, 2008 |
| Priority date | — |
| Expiry date | Jun 29, 2025 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J31/1805
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A material includes a surface and a reactive agent that is located at the surface of the material, covalently attached to a backbone of the material, and/or located within the material. The reactive agent has nitrite reductase activity, nitrate reductase activity, and/or nitrosothiol reductase activity. The reactive agent also converts at least one of nitrites, nitrates and nitrosothiols to nitric oxide when in contact with blood. A reproducible nitrosothiol sensor is also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.