Method and composition for treating osteoporosis

US7335686B2 · kind B2 · utility

Assignee

• COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH · IN

Inventors

• Kanury Rao · New Delhi, IN
• Mohan Ramachandran Wani · Jamkhed, IN
• Venkatasamy Manivel · New Delhi, IN
• Parameswaran Subrayan · Margao, IN
• Vinod Singh · Kanpur, IN
• Ramasamy Anand · Kanpur, IN
• Ehrlich Desa · Margao, IN
• Gyan Mishra · Pune, IN
• Anil Chatterji · Margao, IN

Key dates

• Filing date: Dec 30, 2003
• Grant date: Feb 26, 2008
• Expiry date: Oct 7, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C309/18
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to a novel class of acidic amino acid/dicarboxylic acid derivatives (sulfonic acid/sulfate derivatives of naturally occurring amino acids and their amides) useful as inhibitors of osteoclastogenesis. The invention also provides methods of using the novel class of acidic amino acid/dicarboxylic acid derivatives of the general formula ZOC—(CRR)m—COOH, wherein: m=2, 3 or 4; Z is OH or NH2; one R in the compound is from the group consisting of SO3H, OSO3H, CH2—SO3H, CH2—OSO3H, and NHSO3H, and the remaining Rs are H or NH2, for inhibition of osteoclastogenesis.