Carbonyl reductase, gene encoding the same, and process for producing optically active alcohols using the same
US7335757B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Sep 17, 2004 |
| Grant date | Feb 26, 2008 |
| Priority date | — |
| Expiry date | Apr 4, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y101/01184
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
According to the present invention, there is provided a novel carbonyl reductase derived from a microbial belonging to the genus Ogataea and a DNA encoding the enzyme. By reducing ketones with the use of the carbonyl reductase, optically active alcohols, in particular, (E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-3,5-dihydroxy-hept-6-enoic acid esters can be produced. The carbonyl reductase according to the present invention is excellent in activity and stereoselectivity. Thus, according to the present invention, there is provided a process for producing optically active alcohols, which are industrially useful as intermediate materials for drugs, pesticides, etc.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.