Process for the preparation of tolterodine
US7335793B2 · kind B2 · utility
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8Claims
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Key dates
| Filing date | Feb 21, 2006 |
| Grant date | Feb 26, 2008 |
| Priority date | — |
| Expiry date | Feb 21, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C233/18
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A novel process prepares tolterodine, i.e. (R)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine, in the racemic form, as well as intermediates useful for its preparation. Tolterodine free base may be prepared by reacting diisopropyl-(3-phenyl-3-p-tolyloxy-propyl)-amine and 60% aqueous sulfuric acid for three hours under stirring at room temperature. The reaction mixture is then poured over ice/water and then alkalized with 50% NaOH.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.