Process for preparing branched ribonucleosides from 1,2-anhydroribofuranose intermediates
US7339054B2 · kind B2 · utility
57Cited by
3References
13Claims
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Key dates
| Filing date | Feb 6, 2004 |
| Grant date | Mar 4, 2008 |
| Priority date | — |
| Expiry date | Feb 6, 2024 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process is provided for the preparation of branched-chain ribonucleosides of formula (I):from the 1,2-anhydroderivatives of formula (II).wherein PG is a hydroxyl protecting group, B is a purine or pyrimidine nucleobase, and R1 is C1-6 alkyl. The compounds of formula (I) are inhibitors of HCV polymerase useful in the treatment of HCV infection.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.