Promoter construct for gene expression in neuronal cells
US7341847B2 · kind B2 · utility
1Cited by
15References
25Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 2, 2003 |
| Grant date | Mar 11, 2008 |
| Priority date | — |
| Expiry date | Nov 19, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2750/14143
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to a chimeric promoter construct useful for neuronal cell specific gene expression. The invention provides a recombinant nucleic acid molecule that comprises a neuronal cell specific promoter such as platelet-derived growth factor β-chain promoter, operably linked to a heterologous enhancer which enhances the transcriptional activity of the promoter, such as cytomegalovirus immediate early gene enhancer. The promoter construct according to the invention can increase and prolong gene expression in neuronal cells and may be advantageously used in gene therapy of neuronal disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.