Rifamycin analogs and uses thereof

US7342011B2 · kind B2 · utility

Assignee

• ActivBiotics, Inc. · US

Inventors

• John H. van Duzer · Phillipsburg, US
• Arthur F. Michaelis · Devon, US
• William B. Geiss · Athens, US
• Douglas G. Stafford · Niskayuna, US
• Joseph Raker · Delmar, US

Key dates

• Filing date: Aug 11, 2004
• Grant date: Mar 11, 2008
• Expiry date: Aug 11, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. In one form, the analogs are acetylated at the 25-position, as is rifamycin. In another form, the analogs are deacetylated at the 25-position. In yet other forms, benzoxazinorifamycin, benzthiazinorifamycin, and benzdiazinorifamycin analogs are derivatized at various positions of the benzene ring, including 3′-hydroxy analogs, 4′- and/or 6′ halo and/or alkoxy analogs, and various 5′ substituents that incorporate a cyclic amine moiety.