Fab-epitope complex from the HIV-1 cross-neutralizing monoclonal antibody 2F5
US7342090B1 · kind B1 · utility
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Key dates
| Filing date | Apr 5, 2000 |
| Grant date | Mar 11, 2008 |
| Priority date | — |
| Expiry date | Apr 5, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/16122
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The crystal structure of the Fab′ fragment of Mab 2F5, a potent neutralizer of both laboratory strains and primary clinical isolates of most clades of HIV-1, both uncompleted and complexed with the largely conserved peptide sequence ELDKWAS of the viral envelope protein gp41, has been elucidated and the characteristics of peptide-protein interactions determined. Having regard to such determination, the peptide-mimetics are constrained in the three-dimensional structure to provide an increased immunogenicity to the epitope sequence.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.