Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof

US7342124B2 · kind B2 · utility

Assignees

• The Trustees of the University of Pennsylvania · US
• Kosan Biosciences Incorporated · US

Inventors

• David C. Myles · Kensington, US
• Mark Burlingame · Oakland, US
• Simon Shaw · Oakland, US
• Kurt Sundermann · Greenville, US
• Brian Scott Freeze · Boston, US
• Ignacio Yague Martin · Getafe, ES
• Tomoyasu Hirose · Tokyo, JP
• Amos B. Smith, III · Yeadon, US

Key dates

• Filing date: Apr 2, 2004
• Grant date: Mar 11, 2008
• Expiry date: Sep 6, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/5442
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided.